Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7209 | 7209-30923 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | L33F, G73S | L10I, I13V, K20R, E35D, M36I, N37D, R41K, I62V, L63P, A71V, I72L |
| >7209-30923| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKMIGGIGGFLKVRQYD QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, L210W, T215Y | K219N | L100I, K103N, Y181C | K43E, E44A, V118I, K122E, I135T, K166R, G196E, R211K, K223Q, L228H, Q242H, V245E, K277R, T286A, A288S, E297R, L301I, F346Y, R356K, M357R, A360I, A376S, K395R, A400T |
| >7209-30923| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDNKHQQEPPFHWMGYELHPDKWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKSLTEVIPLTREAE IELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYAKRRGI HTNDVKQLTEAVQKISTESIVIWGKTPKFKLPIQRETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |