Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9049 | 9049-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | Y181C, G190A | V108I, F227L | T39A, E44D, K101Q, L109LI, V118I, K122E, I135T, I195M, E203K, H208Y, H221Y |
| >9049-30929| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTIIDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEMGQHRTKIKELRQYLWRWGFYTP DNKYQKEPPLLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V | L10I, T12K, I13IV, L19I, E35D, N37D, I64V, I66F, A71V, P79A, T91A, Q92K, I93V |
| >9049-30929| codons 4-99 TLWQRPIVKVKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFVKVRQYDQIL VEFCGHKVIGTVVVGATPVNVIGRNLLAKVGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |