Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9043 | 9043-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | K43T | L10I, T12N, I15V, L19Q, K20M, E35N, M36I, R41K, K55R, I62V, L63P, A71V, T74S |
| >9043-30925| codons 4-99 TLWQRPIVNIKVGGQQMEALLDTGADDTVLENINLPGKWTPKIIGGVGGFVRVRQYDQVP IEICGHKVIGSVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | E44D, K64R, V118I, K122E, I135T, S162C, V179I, Q197K, T200A, Q207E, H208Y, R211RK, D218E, V245E |
| >9043-30925| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIIICQYVDDLYVASDLEIGKHRAKIEELREYLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |