Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9042 | 9042-30924 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V, T215Y | K219E | Y188L, M230ML | T39A, K49R, S68G, K102Q, L109I, K122E, I135T, S162C, I178IM, F227Y, D237DN, V245M |
| >9042-30924| codons 38-247 CAEMEKEGKISRIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKQKKSVTVIDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDMVIYQYVDDLLVGSDLEIGQHRTKIEELRQHLLRWGFYTP DEKHQKEPPYLWLGYELHPNKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | L33F, G73C | L10I, T12N, I13V, G16E, K20V, E34EQ, K55R, R57K, Q61D, I72R, V77I |
| >9042-30924| codons 4-99 TLWQRPIVNVKIEGQLVEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGFLRVKQYDDIL IEICGHKARCTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |