Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9140 | 9140-30930 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LV, T12N, I15V, K20R, E35D, M36I, R41K, K55KR, R57K, Q61N, L63A, E65D, K70Q, I93IL |
| >9140-30930| codons 4-99 TLWQRPVVNIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIRVKQYDNIA IDICGHQAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103KN | V90VI, D123E, I135L, S162CW, K166KQ, E169D, K173A, Q174K, D177N, T200A, R211K, V245Q |
| >9140-30930| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQWSMTQILDPFRAKNPNIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |