Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9130 | 9130-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30DN, M46I, V82A | N88D | I15V, K20M, E35DG, M36I, N37E, R41K, K43KR, K55R, R57K, Q61N, L63P, I93L |
| >9130-30918| codons 4-99 TLWQRPLVTIKVGGQLMEALLDTGADNTVLEGIELPGKWRPKIIGGIGGFIRVKQYDNIP IEICGHKAIGTVLVGPTPANIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75VM, T215Y | K103N, G190A | R83K, V90I, V118VI, I178M, T200A, R211K, L228H |
| >9130-30918| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKKTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYMDDLYVASDLEIGQHRAKIEELRQHLLKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |