Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9135 | 9135-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46FL, I54V, V82A | L24I, L33F, K43T, G73S | L10I, T12K, I15V, G16D, L19IM, K20M, E35DN, M36I, P39PS, K55R, I62V, L63P, A71V |
| >9135-30918| codons 4-99 TLWQRPIVKIKVDGQMMEALIDTGADDTVFENINLSGRWTPKLIGGIGGFVRVRQYDQVP IEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, V75M, Y115F, Q151M, T215Y | F77L, F116Y | T39A, E53D, K101Q, V111VIM, K122E, D123N, I135IT, S162Y, I167V, I178L, H208Y, R211K, V245E |
| >9135-30918| codons 38-247 CAELEKEGKISKIGPDNPYNTPVFAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDMGDAFYSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQYSMTKVLEPFRKQNPDLVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLLKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |