Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9143 | 9143-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10FI, G73S | T12P, K14R, K20KT, E34Q, P39Q, R41K, L63P, I66V, A71T, I72R, V77I, P79D, T91S, I93L, C95F |
| >9143-30929| codons 4-99 TLWQRPIVPIRIGGQLTEALLDTGADDTVLQEMNLQGKWKPKIIGGIGGFVKVRQYDQIP IEVCGHKTRSTVLIGDTPVNVIGRNLMSQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, L210W, T215Y | G190GRS | E44D, K64R, K101KQ, V111I, V118I, D123E, I135T, E169D, K173E, V179I, Q207E, H208Y, R211K |
| >9143-30929| codons 38-244 CTELEKDGKISKIGPENPYNTPVFAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDIGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILDPFREQNPDIIIYQYMDDLYVSSDLEIGQHRTKIEELREYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPI |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |