Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9144 | 9144-30909 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, T215F | D67ST, Q151QL, K219E | K101E, Y181C, G190A | A98AG, V108I, F227L | T69N, V90I, K103R, K122E, R172K, D177E, G196E, T200A, E203K, K223E, L228R |
| >9144-30909| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKTSNRWRKLVDFRELNKRTQDFWEIQLGIPHP GGLEKRKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPLGWKGSP AIFQSSMTKILEPFKKQNPEIVICQYMDDLYVASDLEIEQHRAKIKELRQHLLRWGFFTP DEKHQEEPPLRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, L90M | L10FI, G73GS, V82VG | T12S, K14R, I15V, K20R, E35D, M36I, N37S, R41K, L63P, A71V, I85V | L24LV, D29DV |
| >9144-30909| codons 4-99 TLWQRPIVSIRVGGQLREALVDTGAVDTILEDISLPGKWKPKMVGGIGGFMKVRQYDQIP IEICGHKVISTVLVGPTPGNIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |