<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9149 9149-30826 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, T215Y D67G, V75A, K219R   V108I T39A, K49R, V111I, S117A, K122E, I135V, S162Y, S163T, E169D, K173T, Q174K, T200A, E203D, Q207E, H208Y, R211K, W212C, H221Y, K223Q, L228R E44Y, M230I, E233V, W239C
>9149-30826| codons 38-242
CAELEKYGKISRIGPENPYNTPVFAIKKKGSDKWRKLADFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTILDIGDAYFAVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQYTMTKILDPFRTKNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELREYLLKCGFYTP
DRKYQQEPPFRWIGYVLHPDKCTVQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, L33F, K43T, F53L L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, K70R, L89LM, Q92K R8P
>9149-30826| codons 4-99
TLWQPPIVTIKVGGQIREALIDTGADDTVFEDIDLPGKWTPKLIGGIGGLVRVKQYDNIP
IEICGHRAIGTVLVGPTPANIIGRNMLTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006