Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9149 | 9149-30826 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, L33F, K43T, F53L | L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, K70R, L89LM, Q92K | R8P |
| >9149-30826| codons 4-99 TLWQPPIVTIKVGGQIREALIDTGADDTVFEDIDLPGKWTPKLIGGIGGLVRVKQYDNIP IEICGHRAIGTVLVGPTPANIIGRNMLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, T215Y | D67G, V75A, K219R | V108I | T39A, K49R, V111I, S117A, K122E, I135V, S162Y, S163T, E169D, K173T, Q174K, T200A, E203D, Q207E, H208Y, R211K, W212C, H221Y, K223Q, L228R, E233V | E44Y, M230I, W239C |
| >9149-30826| codons 38-242 CAELEKYGKISRIGPENPYNTPVFAIKKKGSDKWRKLADFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDIGDAYFAVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYTMTKILDPFRTKNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELREYLLKCGFYTP DRKYQQEPPFRWIGYVLHPDKCTVQ |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |