Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9146 | 9146-30825 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L33I, N88D | I15V, E35D, M36I, N37S, R41K, I62V, L63P, A71T, I85V |
| >9146-30825| codons 4-99 TLWQRPLVTIKVGGQLKEALLDTGADDTVIEDISLPGKWKPKMIGGIGGFIKVRQYDQVP IEICGHKTIGTVLVGPTPVNIVGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, T215F | K103KN, Y181YC | V108VI, K238KT | K122KE, K126KE, I135M, I142IV, H221HY |
| >9146-30825| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEDFREYTAFTIPSMNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTP DKKYQKEPPFLWMGYELHPDTWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |