Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9121 | 9121-30930 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, Q58E, G73T | E34Q, I62V, L63P, I66V, C67F, H69Q, I72LV, V77VI, I93L | V11G |
| >9121-30930| codons 4-99 TLWQRPFGTIKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVKVREYDQVP IEVFGQKAVTTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, L210W, T215Y | K219E | Y181C, G190A | K101HN, V108I | E40F, K43E, V106VI, L109LV, V118I, D123E, D177E, V189VI, Q197E, T200TI, D218E, L228H, H235HR, I244M, V245M | D76DN, S162ADHP |
| >9121-30930| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKNSTRWRKITNFRELNKRTQDFWEVQLGIPHP AGLNKKKSITIVDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQPSMTKILEPFRKQNPEIVICQYMDDLYIASDLEIGEHRIKIEELRQHLWRWGFYTP EEKHQKEPPFHWMGYELRPDKWTVQPMMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |