Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9112 | 9112-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54V, V82A, L90M | G73S | L10I, L19V, K55R, I62IV, L63P, C67F, H69Q, A71V, C95CFLR |
| >9112-30918| codons 4-99 TLWQRPIVTIKIGGQVKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVRVRQYDQVP IEIFGQKVISTVLVGPTPANIIGRNLMTQIGRTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184MV | K219Q | K103N | T39M, V60I, T69N, K104KQ, K122E, I135T, T200A, R211RK, V245E |
| >9112-30918| codons 38-247 CMEMEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNQSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTP DQKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |