Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9114 | 9114-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75T, M184V, L210W, T215Y | D67G, K219DN | K103N, Y181C | A98AG, V108I | E44D, S68G, K101KR, V111VIM, D123E, I135T, I142V, Q174K, I178L, G196E, E203ED, H221Y, D237E |
| >9114-30918| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKGGTKWRKITDFRELNKRTQDFWEVQLGIPHP GGLRKNKSVTILDMGDAYFSVPLDKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPDLVICQYVDDLYVGSDLEIEQHRTKIDELRQHLWRWGFYTP DNKYQKEPPFLWMGYELHPEKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | K43T | L10I, T12K, I15V, L19I, N37E, K55KR, R57RK, I62V, L63P, A71V, L89LM, I93L |
| >9114-30918| codons 4-99 TLWQRPIVKIKVGGQIKEALLDTGADDTVLEEMELPGRWTPKIIGGIGGFVRVKQYDQVP IEICGHKVIGTVVVGPTPANIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |