<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9114 9114-30918 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M K43T L10I, T12K, I15V, L19I, N37E, K55KR, R57RK, I62V, L63P, A71V, L89LM, I93L  
>9114-30918| codons 4-99
TLWQRPIVKIKVGGQIKEALLDTGADDTVLEEMELPGRWTPKIIGGIGGFVRVKQYDQVP
IEICGHKVIGTVVVGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, V75T, M184V, L210W, T215Y D67G, K219DN K103N, Y181C A98AG, V108I E44D, S68G, K101KR, D123E, I135T, I142V, Q174K, I178L, G196E, E203ED, H221Y, D237E V111VIM
>9114-30918| codons 38-247
CTELEKDGKISKIGPENPYNTPVFAIKKKGGTKWRKITDFRELNKRTQDFWEVQLGIPHP
GGLRKNKSVTILDMGDAYFSVPLDKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKKNPDLVICQYVDDLYVGSDLEIEQHRTKIDELRQHLWRWGFYTP
DNKYQKEPPFLWMGYELHPEKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006