Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9111 | 9111-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | V11I, L24I, G73S | L10I, A22V, E35D, M36I, N37D, R41K, K55KR, R57K, D60E, Q61D, I62V, L63P, A71V, I72T |
| >9111-30918| codons 4-99 TLWQRPIITIKIGGQLKEVLIDTGADDTVLEDIDLPGKWKPKLIGGIGGFVRVKQYEDVP IEICGHKVTSTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, M184V, T215F | V75I, K219Q | L100I, K103N | T39A, E40D, V118I, E169D, T200A, R211T, F214L, L228H, V245E | K223KI |
| >9111-30918| codons 38-247 CADLEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLTWGLFTP DQKHQIEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |