Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9107 | 9107-30915 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, L76V, I84V, L90M | V11I, G73GDNS, L89V | L10I, I13V, I15V, K20V, M36MI, R57K, I62V, L63P, A71IV, T74S, T91TS, Q92K |
| >9107-30915| codons 4-99 TLWQRPIITVKVGGQLVEALLDTGADDTVLEEINLPGRWKPKIVGGIGGFVKVKQYDQVP IEICGHKVISSVVVGPTPVNVIGRNVMSKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219R | Y188L, G190A | A98G | K43KQ, E44D, K64R, D123E, I135T, I142V, S162C, D177E, V179I, I202T, H208Y, R211K, K223Q, L228H, V245E | N57NH |
| >9107-30915| codons 38-247 CTELEQDGKISKIGPENPYHTPVFAIRKKGSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIIIYQYVDDLLVASDLEIGQHRTKTEELRQYLWKWGFYTP DRKHQQEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |