Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9108 | 9108-30915 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I13V, L19I, L38LF, L63A, H69Y, A71V, V77I | R8Q |
| >9108-30915| codons 4-99 TLWQQPLVTVKIGGQIKEALLDTGADNTVLEEMNFPGRWKPKMIGGIGGFIKVRQYDQIA IEICGYKVIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K122E, I135V, Q174H, T200A, P243T | Q85Q* |
| >9108-30915| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRT*DFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKHNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQTIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |