Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9154 | 9154-30930 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54L, I84V, L90M | L33F, G73T | L10I, E35ED, M36L, Q61N, L63P, I64V, I66F |
| >9154-30930| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTIFEDLNLPGRWKPKMVGGIGGFLKVRQYDNIP VEFCGHKAITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | K101E, Y181I, G190A | V179D | A98S, K104Q, V118I, K122E, D123DGNS, I135T, E138EG, R211K, F214L, D218E, L228H, D237N |
| >9154-30930| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLEKKQSVTVLDVGDAYFSIPLDESFRKYTAFTIPSTNNGTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIDIIQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGLFTP EQKHQKEPPFHWMGYELHPNKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |