Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9168 | 9168-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10FI, L33F, G73S | T12P, I13V, K14R, G16A, K20T, M36MI, I62IV, L63P, I66V, A71T, I93L, C95F |
| >9168-30929| codons 4-99 TLWQRPIVPVRIAGQLTEALLDTGADDTVFEEINLPGRWKPKIIGGIGGFVKVRQYDQVP IEVCGHKTISTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, M184V, T215FY | T69G, K219E | K101E, Y181C, G190A | V108I | T39A, K43Q, E44D, D67X, K122E, I135T, E169ED, G196E, E203EA, L210LF, R211K, L228H, Q242H, V245E |
| >9168-30929| codons 38-246 CAELEQDGKISKIGPENPYNTPVFAIKKKXSGRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIVICQYVDDLYVASDLEIEQHRTKIAELRQHLFKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVHPIEL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |