<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9168 9168-30929 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L10FI, L33F, G73S T12P, I13V, K14R, G16A, K20T, M36MI, I62IV, L63P, I66V, A71T, I93L, C95F  
>9168-30929| codons 4-99
TLWQRPIVPVRIAGQLTEALLDTGADDTVFEEINLPGRWKPKIIGGIGGFVKVRQYDQVP
IEVCGHKTISTVLVGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74V, M184V, T215FY T69G, K219E K101E, Y181C, G190A V108I T39A, K43Q, E44D, D67X, K122E, I135T, E169ED, G196E, E203EA, L210LF, R211K, L228H, Q242H, V245E  
>9168-30929| codons 38-246
CAELEQDGKISKIGPENPYNTPVFAIKKKXSGRWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLEKKKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILDPFRKQNPDIVICQYVDDLYVASDLEIEQHRTKIAELRQHLFKWGFYTP
DEKHQKEPPFHWMGYELHPDKWTVHPIEL

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006