Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9372 | 9372-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82T, I84V | L10I, I13V, K14KN, G16E, K20R, M36I, L63T, H69Q, T74A, L89I |
| >9372-30929| codons 4-99 TLWQRPIVTVNIEGQLREALLDTGADDTVLEEINLPGRWKPKLIVGIGGFVKVRQYDQIT IEICGQKAIGAVLVGPTPTNVIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103KNRS, G190A | K43Q, V118I, I135T, S162SN, G196E, R211K, V245E |
| >9372-30929| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |