Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9166 | 9166-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | V75I, F77L, F116Y | Y188YH | S48T, S68G, K122E, D123S, Q174H, D177E, V179I, T200A, I202IV, R211S, F214L |
| >9166-30925| codons 38-247 CTEMEKEGKITKIGPENPYNTPVFAIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLDESFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKHNPEIIIYQYMDDLHVGSDLEIGQHRAKVEELRQHLLSWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90LM | L10F, L33I, N88D | E35D, M36I, R41K, I62IMV, L63P, L89F, I93L |
| >9166-30925| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADNTVIEDINLPGKWKPKMIGGIGGFIKVRQYDQVP IEICGHKAIGTVLVGPTPVNIIGRDFMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |