Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9162 | 9162-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K101E, Y181C, G190A | T39A, E44D, V118I, K122P, D123E, I135T, Q174R, I178IM, V179I, G196E, T200IL, E203K, H208Y, R211K, W212M, K223E, L228H, V245K |
| >9162-30925| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSIPLDPEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDMIICQYMDDLYVASDLEIEQHRLKIKELRQYLWKMGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, Q58E, G73S | T12K, I13V, I15V, L19V, K20I, M36I, I62V, L63P, C67F, A71T, I72V, P79D, T91S |
| >9162-30925| codons 4-99 TLWQRPFIKVKVGGQVIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYDQVP IEIFGHKTVSTVLVGDTPVNVIGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |