Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9158 | 9158-30924 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L23LI, L33F, Q58E | K20R, E35D, M36I, K55R, D60E, I62V, L63P, A71V, T91S, I93L |
| >9158-30924| codons 4-99 TLWQRPFVTIKIGGQLREAILDTGADDTVFEDINLPGRWKPKLIGGIGGFVRVREYEQVP IEICGHKVIGTVLVGPTPANIIGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | A62V, K219N | L100I, K103N | K43E, E44A, K102KR, V118VIM, K122E, D177G, T200A, E203D, Q207E, H208Y, R211K, D218E, L228H, V245M |
| >9158-30924| codons 38-247 CTELEEAGKISKIGPENPYNTPVFVIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAYFSMPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTP ENKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |