<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9158 9158-30924 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L10F, L23LI, L33F, Q58E K20R, E35D, M36I, K55R, D60E, I62V, L63P, A71V, T91S, I93L  
>9158-30924| codons 4-99
TLWQRPFVTIKIGGQLREAILDTGADDTVFEDINLPGRWKPKLIGGIGGFVRVREYEQVP
IEICGHKVIGTVLVGPTPANIIGRNLMSQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y A62V, K219N L100I, K103N   K43E, E44A, K102KR, V118VIM, K122E, D177G, T200A, E203D, Q207E, H208Y, R211K, D218E, L228H, V245M  
>9158-30924| codons 38-247
CTELEEAGKISKIGPENPYNTPVFVIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGIKRNKSVTVLDVGDAYFSMPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTP
ENKHQKEPPFHWMGYELHPDKWTVQPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006