Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9006 | 9006-30923 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219E | Y181C | A98G, K101HQ | K122E, D123S, I135T, D177E, Q197L, T200A, E203EA, Q207E, V245T | V60VIM |
| >9006-30923| codons 38-247 CTEMEKEGKISKIGPENPYNTPMFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLQKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVGSDLEIGLHRAKIAELREHLLRWGFYTP DEKHQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A | L24I, Q58E, L89V | L10Y, I13IMV, I15V, K20I, E34KQ, E35D, M36I, N37NS, R41K, R57K, D60E, I62IV, L63P, A71V, I93L |
| >9006-30923| codons 4-99 TLWQRPYVTVKVGGQLIEALIDTGADDTVLQDISLPGKWKPKMIGGIGGFAKVKEYEQVP IEICGHKVIGTVLVGPTPANIIGRNVLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |