Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9008 | 9008-30923 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10F, L24I, L33F, G73T | L19I, K20R, E35D, M36I, R41K, L63P, A71V, I72IM |
| >9008-30923| codons 4-99 TLWQRPFVTIKIGGQIREALIDTGADDTVFEDINLPGKWKPKMIGGIGGFVKVRQYDQIP IEICGHKVMTTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | Y181C, G190A | K101H | T39A, V60I, K103R, K122P, I135T, A158S, D177E, R211K, D218E, L228H, V245L | H235HR |
| >9008-30923| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKRKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTP EQKHQKEPPFHWMGYELRPDKWTVQPILLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |