<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9001 9001-30922 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, L90M Q58E, G73GA L10I, V11VL, K20R, E35D, M36I, N37E, F53FY, K55KR, R57RK, D60E, L63P, A71V, V77I, V82I, I85IV, I93L R8RL
>9001-30922| codons 4-99
TLWQLPILTIKIGGQLREALLDTGADDTILEDIELPGRWKPKIVGGIGGYMRVKEYEQIP
IEICGHKVIATVLIGPTPINIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y K219E K101EQ, Y181C, G190A V108VI, E138EAKT T39A, E40D, E44D, L109LIMV, V118I, K122E, I135T, I142IT, D218DE, L228H  
>9001-30922| codons 38-247
CADLEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTIVDVGDAYFSIPLDEDFRKYTAFTIPSTNNTTPGTRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTP
EEKHQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006