Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9001 | 9001-30922 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | Q58E, G73GA | L10I, V11VL, K20R, E35D, M36I, N37E, F53FY, K55KR, R57RK, D60E, L63P, A71V, V77I, V82I, I85IV, I93L | R8RL |
| >9001-30922| codons 4-99 TLWQLPILTIKIGGQLREALLDTGADDTILEDIELPGRWKPKIVGGIGGYMRVKEYEQIP IEICGHKVIATVLIGPTPINIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219E | K101EQ, Y181C, G190A | V108VI, E138EAKT | T39A, E40D, E44D, L109LIMV, V118I, K122E, I135T, I142IT, D218DE, L228H |
| >9001-30922| codons 38-247 CADLEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTIVDVGDAYFSIPLDEDFRKYTAFTIPSTNNTTPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLWRWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |