Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9088 | 9088-30827 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A | L33F, K43KT, F53L, N83D | L10I, I13V, L19I, K20R, E35D, M36I, N37C, R57K, I62V, L63Q, I64V, C67Y, I72V, V75I, T91TA |
| >9088-30827| codons 4-99 TLWQRPIVTVKIGGQIREALLDTGADDTVFEDICLPGRWTPKMIVGIGGLVKVKQYDQVQ VEIYGHKAVGTILVGPTPADIIGRNLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67G, K70T, K219N | V108VI | E40F, K43E, S68G, V118I, K122P, Q174QR, D177E, I178F, E203K, Q207D, H208Y, R211K, K223Q, L228H |
| >9088-30827| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKGGTTWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSIPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPEFVIYQYMDDLYVGSDLEIGQHRTKIKELRDYLWKWGFYTP DNKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |