Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9085 | 9085-30827 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82VA, L90M | L33F, G73GS | L10I, T12K, I13V, L19I, Q61QH, L63P, E65ED, H69Q, A71AV, V77I, I93M |
| >9085-30827| codons 5-99 LWQRPIVKVKIGGQIKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYDHIPI DICGQKVISTVLIGPTPANIIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, L210LW, T215Y | V106VA, Y181YC, G190GA | V108VI | T39A, E44D, K102KQ, K122P, I135T, S162SC, F171FY, D177E, G196E, T200TA, E203EK, Q207E, K223KE, L228LH |
| >9085-30827| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKQKKSATILDVGDAYFSVPLDPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPYRKQNPEIVICQYMDDLYVASDLEIEQHRAKIKELREHLWRWGFYTP DKKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |