Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9091 | 9091-30827 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, M184V, T215FV | F116Y, K219Q | K101E, Y181C, G190A | V108VI | T39A, V60I, T69N, K122E, D123N, I135T, S162SC, I167V, D177E, I178L, V179I, G196E, H208Y, D218E, L228HQ, V245IM |
| >9091-30827| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAYYSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQCSMTKVLEPFRKQNPELIICQYVDDLYVASDLEIEQHRTKIEELRQYLLRWGFVTP EQKHQKEPPFQWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, L33F, Q58E, G73S, L89V | L10I, I13V, L24F, N37D, K55R, D60DN, I62V, L63P, K70KN, A71I, I72M, V77I, C95L |
| >9091-30827| codons 4-99 TLWQRPIITVKIGGQLKEALFDTGADDTVFEEMDLPGRWKPKLIGGIGGFVRVREYNQVP IEICGHNIMSTVLIGPTPANIIGRNVMTQIGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |