Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9318 | 9318-30923 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | K101DE, Y181C, G190A | V108I | E44D, K64KR, K103KR, V118I, K122E, I135T, T165TI, D177E, I178IM, V189VI, R211K, D218E |
| >9318-30923| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIRKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLEKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPEMVICQYVDDLYIASDLEIGQHRTKIEELRQHLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F, L90M | L23I, Q58E | L10I, K14R, K20R, E35D, M36I, N37D, I62V, L63P, I64V, A71V, I93L |
| >9318-30923| codons 4-99 TLWQRPIVTIRIGGQLREAILDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVREYDQVP VEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |