Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9235 | 9235-30917 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54IL, L76V, I84V, L90M | L10FI, G73GAST | I13IM, Q18QHR, K20I, E34EQ, E35D, N37DE, L63P, I64V, H69HR, K70R, A71AV, I72IL, I85IV, T91TS |
| >9235-30917| codons 4-99 TLWQRPIVTMKIGGRLIEALLDTGADDTVLQDMELPGRWKPKIVGGIGGFLKVRQYDQIP VEICGRRVLTTVVVGPTPVNVVGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K219R | G190GA | F227FL | E44D, V118I, K122E, I142IV, E203K, Q207DE, H208HY, R211K, K223Q |
| >9235-30917| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYIDDLYVASDLEIGQHRTKIKELREYLWKWGFYTP DRKHQQEPPLLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |