Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9230 | 9230-30915 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, N88S | L10I, I13V, L19V, K20I, E35ED, N37S, L63P, I66IV, A71T, I72IT, I85IV, I93L |
| >9230-30915| codons 4-99 TLWQRPIVTVKIGGQVIEALLDTGADDTVLEDMSLPGRWKPKIIGGIGGFIKVRQYDQIP IEVCGHKTTGTVLVGPTPVNVVGRSLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V, T215F | V75A, K219E | K103N | K64H, V118VI, K122E, I142T, T200A, Q207G, R211RK, D218E, L228LF, V245EK |
| >9230-30915| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKNSTRWRKIADFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRGHLLKWGFFTP EEKHQKEPPFFWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |