Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9228 | 9228-30911 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IL, L76V, I84V, L90M | L10F, V11I, L33F, G73S | I13V, G16A, E34EQ, I62V, L63P, A71V, I72L |
| >9228-30911| codons 4-99 TLWQRPFITVKIAGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFLKVRQYDQVP IEICGHKVLSTVVVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | Y188L | V60VI, T69TNSY, K102KR, V118I, K122P, I135T, V179I, G196E, I202V, F214L, D237E, I244IM |
| >9228-30911| codons 38-246 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSYRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRKKSVTVLDVGDAYFSIPLDPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIEQHRTKVEELRQHLLRWGLFTP DQKHQKEPPFLWMGYELHPEKWTVQPMVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |