Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9018 | 9018-30909 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | A62V, V75I, F77L, F116Y, M184L, K219E | K101E, Y181C | V108I | S68G, F87FS, D123E, D177E, T200A, Q207K, R211T, V245E | Q182N, Y183T |
| >9018-30909| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDGTKWRKLIDLRELNKRTQDSWEVQLGIPHP AGLEKKKSVTILDVGDAYYSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPEIVICNTLDDLYVGSDLEIGQHRAKIEELRKHLLTWGFTTP DEKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47IV, I54V, V82A, L90M | F53L, G73S | L10I, I13IV, I15V, G16A, K20I, L24LF, M36MI, K55R, I62IV, L63P, A71V, I72IL, N83NS |
| >9018-30909| codons 4-99 TLWQRPIVTVKVAGQLIEALFDTGADDTVLEEINLPGRWKPKIVGGIGGLVRVRQYDQVP IEICGHKVLSTVLVGPTPASIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |