Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9014 | 9014-30908 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70E, V75T, Q151M | F77L, F116Y | K101E, Y181C, G190A | T58N, V60I, K73M, D121H, K122E, I135T, T139A, Y146H, I178M, F214L, H221Y, V245N |
| >9014-30908| codons 38-247 CTEMEKEGKISKIGPENPYNNPIFAIKKKNSTEWRMLTDLRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYYSVPLHEDFRKYTAFTIPSTNNEAPGIRYQHNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDMVICQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP DKKYQKEPPFLWMGYELHPDKWTVQPINLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | G73S | L10I, E35D, M36I, N37D, I62V, L63P, A71V, I72L |
| >9014-30908| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |