Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9287 | 9287-30930 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74LV | A62V | K101KE, Y181I | K122E, I135T, H221HY, V245I |
| >9287-30930| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIIQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTP DKKYQKEPPFLWMGYELHPDKWTVQPIILP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F | L19I, N37S, R57K, L63P, A71V, V77I, L89I, I93L |
| >9287-30930| codons 4-99 TLWQRPFVTIKIGGQIKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFVKVKQYDQIP IEICGHKVIGTVLIGPTPANIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |