Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9294 | 9294-30930 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, L210W, T215F | K219Q | Y181C, G190A | K101H, V108VI | T69N, V118VI, K122E, S162D, R211RK, D218E, V245K |
| >9294-30930| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKITDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, V82A | L24I | L10I, I15IV, E35D, M36I, N37ND, R41K, I62V, L63P, T74S |
| >9294-30930| codons 4-99 TLWQRPIVTIKVGGQLKEALIDTGADDTVLEDIDLPGKWKPKIIGGIGGFIKVRQYDQVP IEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |