Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9282 | 9282-30929 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T, I84V, L90M | K43T | L10I, T12P, I15V, K20R, E35D, M36I, K55R, I62V, L63P, A71LV, I72T, I85V, Q92K, I93IL |
| >9282-30929| codons 4-99 TLWQRPIVPIKVGGQLREALLDTGADDTVLEDINLPGRWTPKIIGGIGGFVRVRQYDQVP IEICGHKVTGTVVVGPTPTNVVGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, T215F | K219Q | Y188L | V106I, L109V, D121Y, K122E, I135T, Q174QK, D177E, V179I, V189I, G196E, I202V, D218E |
| >9282-30929| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVVDVGDAYFSVPLYEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPEIIIYQYMDDLLIGSDLEIEQHRTKVEELRQHLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |