Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9279 | 9279-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, K70T, V75I, F77L, F116Y | V108I | T58N, S68G, T69TN, D121H, K122E, I135T, D177E, V245K | I63IL |
| >9279-30925| codons 38-247 CTEMEKEGKISKIGPENPYNNPVFVLKKKDGNTWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAFYSVPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, Q58E, N88D | I15V, G16A, L19P, K20I, A22V, E35D, M36I, N37Q, D60E, I62V, L63P, C67F, H69Q, K70E, A71V, I72T, I85V, T91S |
| >9279-30925| codons 4-99 TLWQRPFVTIKVAGQPIEVLLDTGADDTVLEDIQLPGRWKPKIIGGIGGFVKVREYEQVP IEIFGQEVTGTVLVGPTPVNVVGRDLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |