Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9280 | 9280-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, Q58QE, G73T | L10I, I13V, K20I, E35D, M36I, N37E, I62V, L63P, C67F, H69R, A71V, I72V, P79A |
| >9280-30925| codons 4-99 TLWQRPIITVKIGGQLIEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVREYDQVP IEIFGRKVVTTVLVGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | K101PQ, K103N | T39A, K43KAET, E44D, I50IT, K102KR, V118I, K122E, R125RK, S162C, G196E, E203K, Q207E, H208Y, R211K, K223E, L228LH |
| >9280-30925| codons 38-247 CAELETDGKISKTGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLQRNKSVTVLDVGDAYFSIPLDEDFKKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |