<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9280 9280-30925 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M V11I, Q58QE, G73T L10I, I13V, K20I, E35D, M36I, N37E, I62V, L63P, C67F, H69R, A71V, I72V, P79A  
>9280-30925| codons 4-99
TLWQRPIITVKIGGQLIEALLDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVREYDQVP
IEIFGRKVVTTVLVGATPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y V75M, K219N K101PQ, K103N   T39A, K43KAET, E44D, I50IT, K102KR, V118I, K122E, R125RK, S162C, G196E, E203K, Q207E, H208Y, R211K, K223E, L228LH  
>9280-30925| codons 38-247
CAELETDGKISKTGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLQRNKSVTVLDVGDAYFSIPLDEDFKKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTP
DNKHQEEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006