Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9281 | 9281-30925 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184MV, L210W, T215Y | K219KR | Y181V, G190A | A98G, K101HQ, V108VI, F227L | K43E, E44A, V118I, K122E, D123DN, I135T, S162D, S163G, K166KR, V179VI, G196E, T200TIM, E203K, R211K, H221HY, K223Q, L228H, V245M | P140T |
| >9281-30925| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLQKKKSVTILDVGDAYFSIPLDENFRKYTAFTIPSTNNETTGIRYQYNVLPQGWKGSP AIFQDGMTRILEPFRKQNPDIIIVQYVDDLYVASDLEIEQHRMKIKELRQHLWKWGFYTP DRKYQQEPPLHWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, G73S | T12S, K14N, I15V, L19Q, K20V, M36I, K55R, R57K, I62V, L63P, A71V, I72L, N83S, I85V |
| >9281-30925| codons 4-99 TLWQRPFISINVGGQQVEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVKQYDQVP IEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |