Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9278 | 9278-30924 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75AS, K219E | K101E, Y181C, G190A | T39TA, E44D, V60VI, V118I, K122E, D123E, K166R, I195T, T200A, E203V, H208Y, R211E, H221HY, L228H, Q242QH, V245M |
| >9278-30924| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSTRWRKLSDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYMDDLYVASDLETGQHRAKIVELRQYLWEWGFYTP DEKYQKEPPFHWMGYELHPDKWTVHPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, V82A, L90M | K43T, F53L, G73C, L89V | L10V, I15V, G16E, Q18H, K20M, E34Q, M36I, P39S, K55R, D60E, I62V, L63P, I85V |
| >9278-30924| codons 4-99 TLWQRPVVTIKVEGHLMEALLDTGADDTVLQEINLSGRWTPKIVGGIGGLLRVRQYEQVP IEICGHKAICTVLVGPTPANIVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |