<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9278 9278-30924 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54L, V82A, L90M K43T, F53L, G73C, L89V L10V, I15V, G16E, Q18H, K20M, E34Q, M36I, P39S, K55R, D60E, I62V, L63P, I85V  
>9278-30924| codons 4-99
TLWQRPVVTIKVEGHLMEALLDTGADDTVLQEINLSGRWTPKIVGGIGGLLRVRQYEQVP
IEICGHKAICTVLVGPTPANIVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y V75AS, K219E K101E, Y181C, G190A   T39TA, E44D, V60VI, V118I, K122E, D123E, K166R, I195T, T200A, E203V, H208Y, R211E, H221HY, L228H, Q242QH, V245M  
>9278-30924| codons 38-247
CAELEKDGKISKIGPENPYNTPIFAIKKKNSTRWRKLSDFRELNKRTQDFWEVQLGIPHP
AGLEKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTRILEPFRKQNPDIVICQYMDDLYVASDLETGQHRAKIVELRQYLWEWGFYTP
DEKYQKEPPFHWMGYELHPDKWTVHPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006