Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9277 | 9277-30923 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I54V, V82A, I84V | L24I, L33F, F53L, Q58E | L10I, L19T, K20R, E34Q, E35D, M36I, N37ND, R41RK, L63P, I64V, V77I |
| >9277-30923| codons 4-99 TLWQRPIVTIKIGGQTREALIDTGADDTIFQDIDLPGKWKPKLIGGIGGLVKVREYDQIP VEICGHKAIGTVLIGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G | L100I, K103N | K43Q, E44EAD, S68G, T69E, V90VI, V118I, K122E, I135T, S162Y, V179I, I195L, T200A, R211Q |
| >9277-30923| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKGGEKWRKVVDFRELNKRTQDFWEIQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLELGQHRAKIEELRQHLWQWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |