Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9259 | 9259-30918 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LI, M184V, L210W, T215Y | Y188L | A98G | T39TA, K43E, V106I, V118I, K122E, V179VI, I202V, R211K, E224D, D237DE, V245M |
| >9259-30918| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIGQHRTKVEELRQHLWKWGFYTP DKKHQKDPPFLWMGYELHPEKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L24I, L33F, K43T, G73S | L10I, I13IV, K20R, E35D, M36V, N37D, K55R, L63P, A71V, T91S |
| >9259-30918| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEDVDLPGRWTPKLIGGIGGFVRVRQYDQIP IEICGHKVISTVLVGPTPANVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |