Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9256 | 9256-30916 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54V, L90M | L33LI, K43KT, F53FL, T74TP | L10IV, I15V, K20R, E35D, M36I, N37D, I62IV, L63P, I64IL, A71AV, V82X, I85IV, L89LM |
| >9256-30916| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTIIEDIDLPGRWTPKIVGGIGGLVKVRQYDQVP LEICGHKVIGPVLVGPTPXNIVGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MV, L210W, T215Y | T39E, E44D, V60I, V118VI, D123E, I135T, K166R, D177DE, I178M, E203ED, H208HY, R211K, L228LH |
| >9256-30916| codons 38-246 CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEMVIYQYVDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |