Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9257 | 9257-30916 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I50IV, I54V, V82M, L90M | L33LFI, K43T, F53FL, T74PS | L10V, I13V, K20R, E35D, M36I, N37D, I62V, L63Q, I64IV, L89LM |
| >9257-30916| codons 4-99 TLWQRPVVTVKIGGQLREALLDTGADDTVIEDIDLPGRWTPKIIGGVGGLVKVRQYDQVQ VEICGHKAIGSVLVGPTPMNIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184MV, L210W, T215Y | K219E | Y181YC | T39E, V60I, K104N, V118I, D121H, K122E, I135T, S162SDGN, V179VI, E194K, I195L, T200A, I202V, H208Y, R211K, D218E, V245M |
| >9257-30916| codons 38-247 CEELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKKNSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIIICQYVDDLYVGSDLKLGQHRAKVEELRQYLWKWGFYTP EEKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |