<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-9257 9257-30916 Brazil 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I50IV, I54V, V82M, L90M L33LFI, K43T, F53FL, T74PS L10V, I13V, K20R, E35D, M36I, N37D, I62V, L63Q, I64IV, L89LM  
>9257-30916| codons 4-99
TLWQRPVVTVKIGGQLREALLDTGADDTVIEDIDLPGRWTPKIIGGVGGLVKVRQYDQVQ
VEICGHKAIGSVLVGPTPMNIIGRNMMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184MV, L210W, T215Y V75M, K219E Y181YC   T39E, V60I, K104N, V118I, D121H, K122E, I135T, S162SDGN, V179VI, E194K, I195L, T200A, I202V, H208Y, R211K, D218E, V245M  
>9257-30916| codons 38-247
CEELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLKKKNSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQNSMTKILEPFRKQNPDIIICQYVDDLYVGSDLKLGQHRAKVEELRQYLWKWGFYTP
EEKHQKEPPFLWMGYELHPDKWTVQPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006