Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-9255 | 9255-30911 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, I84V, L90M | L10F, L33F, K43KT, T74P | V11L, I13V, E34Q, I62V, L63P, H69R, A71V, I72V, V77VI, I93L |
| >9255-30911| codons 4-99 TLWQRPFLTVKIGGQLKEALLDTGADDTVFQEMNLPGRWTPKIVGGIGGFLKVRQYDQVP IEICGRKVVGPVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184MI, L210W, T215F | A62V, K219W | K103N, Y181C, G190A | K65KE, K101Q, K122E, I202V, Q207E, H208Y, R211K, I244IM |
| >9255-30911| codons 38-246 CTEMEKEGKISKIGPENPYNTPVFVIKEKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYIDDLYVASDLEIGQHRTKVEELREYLWKWGFFTP DWKHQKEPPFLWMGYELHPDKWTVQPMVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |